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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50198065
Substrate
n/a
Meas. Tech.
ChEMBL_432539 (CHEMBL918833)
Ki
6.32±n/a nM
Citation
 Collina, S; Loddo, G; Urbano, M; Linati, L; Callegari, A; Ortuso, F; Alcaro, S; Laggner, C; Langer, T; Prezzavento, O; Ronsisvalle, G; Azzolina, O Design, synthesis, and SAR analysis of novel selective sigma1 ligands. Bioorg Med Chem 15:771-83 (2006) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50198065
Synonyms:
4(E)-N-Benzyl-3-(biphenyl-4-yl)-N-methylbut-2-en-1-amine | CHEMBL1917697 | CHEMBL224099 | benzyl-((E)-3-biphenyl-4-yl-but-2-enyl)-methyl-amine
Type:
Small organic molecule
Emp. Form.:
C24H25N
Mol. Mass.:
327.462
SMILES:
CN(C\C=C(/C)c1ccc(cc1)-c1ccccc1)Cc1ccccc1
Structure:
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