Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50198257
Substrate
n/a
Meas. Tech.
ChEMBL_422114 (CHEMBL908799)
IC50
179±n/a nM
Citation
 Jackson, CM; Blass, B; Coburn, K; Djandjighian, L; Fadayel, G; Fluxe, AJ; Hodson, SJ; Janusz, JM; Murawsky, M; Ridgeway, JM; White, RE; Wu, S Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias. Bioorg Med Chem Lett 17:282-4 (2006) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50198257
Synonyms:
2-(3,4-dichlorophenyl)-3-(3-methoxybenzyloxy)thiazolidin-4-one | CHEMBL387102
Type:
Small organic molecule
Emp. Form.:
C17H15Cl2NO3S
Mol. Mass.:
384.277
SMILES:
COc1cccc(CON2C(SCC2=O)c2ccc(Cl)c(Cl)c2)c1
Structure:
Search PDB for entries with ligand similarity: