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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50199066
Substrate
n/a
Meas. Tech.
ChEMBL_411693 (CHEMBL913527)
IC50
160±n/a nM
Citation
 Trotter, BW; Nanda, KK; Kett, NR; Regan, CP; Lynch, JJ; Stump, GL; Kiss, L; Wang, J; Spencer, RH; Kane, SA; White, RB; Zhang, R; Anderson, KD; Liverton, NJ; McIntyre, CJ; Beshore, DC; Hartman, GD; Dinsmore, CJ Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation. J Med Chem 49:6954-7 (2006) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50199066
Synonyms:
1-{[(2R)-2,3-dihydroxypropyl]oxy}-6-methoxy-4-phenylisoquinoline-3-carbonitrile | CHEMBL383997
Type:
Small organic molecule
Emp. Form.:
C20H18N2O4
Mol. Mass.:
350.3679
SMILES:
COc1ccc2c(OC[C@H](O)CO)nc(C#N)c(-c3ccccc3)c2c1
Structure:
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