Reaction Details Report a problem with these data
Target
TGF-beta receptor type-1
Ligand
BDBM50613917
Substrate
n/a
Meas. Tech.
ChEMBL_2294673
IC50
4.7±n/a nM
Citation
 Kang, BN; Kang, HJ; Kim, S; Lee, J; Lee, J; Jeong, HJ; Jeon, S; Shin, Y; Yoon, C; Han, C; Seo, J; Yun, J Synthesis and biological evaluation of N-(3-fluorobenzyl)-4-(1-(methyl-d Bioorg Med Chem Lett 85:0 (2023) [PubMed] 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50613917
Synonyms:
CHEMBL5271258
Type:
Small organic molecule
Emp. Form.:
C23H19FN6
Mol. Mass.:
398.4356
SMILES:
Cc1cccc(n1)-c1[nH]c(NCc2cccc(F)c2)nc1-c1ccc2[nH]ncc2c1
Structure:
Search PDB for entries with ligand similarity: