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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50204585
Substrate
n/a
Meas. Tech.
ChEMBL_454458 (CHEMBL902547)
IC50
11±n/a nM
Citation
DiMauro, EF; Newcomb, J; Nunes, JJ; Bemis, JE; Boucher, C; Buchanan, JL; Buckner, WH; Cheng, A; Faust, T; Hsieh, F; Huang, X; Lee, JH; Marshall, TL; Martin, MW; McGowan, DC; Schneider, S; Turci, SM; White, RD; Zhu, X Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR. Bioorg Med Chem Lett 17:2305-9 (2007) [PubMed] Article
More Info.:
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
Inhibitor
Name:
BDBM50204585
Synonyms:
(S)-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine | CHEMBL247480
Type:
Small organic molecule
Emp. Form.:
C29H32N4O3
Mol. Mass.:
484.5894
SMILES:
C(CN1CCCC1)Oc1ccc(cc1)-c1oc2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1