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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50206577
Substrate
n/a
Meas. Tech.
ChEMBL_428724 (CHEMBL915240)
Ki
250±n/a nM
Citation
 Prezzavento, O; Campisi, A; Ronsisvalle, S; Li Volti, G; Marrazzo, A; Bramanti, V; Cannavò, G; Vanella, L; Cagnotto, A; Mennini, T; Ientile, R; Ronsisvalle, G Novel sigma receptor ligands: synthesis and biological profile. J Med Chem 50:951-61 (2007) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50206577
Synonyms:
10-methoxyibogamine | CHEMBL222287 | IBOGAINE
Type:
Small organic molecule
Emp. Form.:
C20H26N2O
Mol. Mass.:
310.4332
SMILES:
CC[C@H]1C[C@H]2C[C@@H]3[C@H]1N(C2)CCc1c3[nH]c2ccc(OC)cc12 |r,TLB:22:12:7:5.4.9,14:13:7:5.4.9,THB:10:8:5.6:2.3,1:2:5.6:8.9,13:6:2.3:8.9|
Structure:
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