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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50208870
Substrate
n/a
Meas. Tech.
ChEMBL_455158 (CHEMBL887188)
EC50
400±n/a nM
Citation
 Sauerberg, P; Mogensen, JP; Jeppesen, L; Bury, PS; Fleckner, J; Olsen, GS; Jeppesen, CB; Wulff, EM; Pihera, P; Havranek, M; Polivka, Z; Pettersson, I Design of potent PPARalpha agonists. Bioorg Med Chem Lett 17:3198-202 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50208870
Synonyms:
(S)-3-(4-(3,5-bis(trifluoromethyl)cinnamyloxy)phenyl)-2-ethoxypropanoic acid | CHEMBL248112
Type:
Small organic molecule
Emp. Form.:
C22H20F6O4
Mol. Mass.:
462.3822
SMILES:
CCO[C@@H](Cc1ccc(OC\C=C\c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(O)=O
Structure:
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