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Target
C-C chemokine receptor type 1
Ligand
BDBM50209000
Substrate
n/a
Meas. Tech.
ChEMBL_443413 (CHEMBL893666)
IC50
30±n/a nM
Citation
 Brown, MF; Bahnck, KB; Blumberg, LC; Brissette, WH; Burrell, SA; Driscoll, JP; Fedeles, F; Fisher, MB; Foti, RS; Gladue, RP; Guzman-Martinez, A; Hayward, MM; Lira, PD; Lillie, BM; Lu, Y; Lundquist, GD; McElroy, EB; McGlynn, MA; Paradis, TJ; Poss, CS; Roache, JH; Shavnya, A; Shepard, RM; Trevena, KA; Tylaska, LA Piperazinyl CCR1 antagonists--optimization of human liver microsome stability. Bioorg Med Chem Lett 17:3109-12 (2007) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50209000
Synonyms:
2-(2-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl)-2-oxoethoxy)-N-(2-aminoethyl)-5-chlorobenzamide | CHEMBL391302
Type:
Small organic molecule
Emp. Form.:
C24H30ClFN4O3
Mol. Mass.:
476.971
SMILES:
C[C@H]1CN([C@H](C)CN1Cc1ccc(F)cc1)C(=O)COc1ccc(Cl)cc1C(=O)NCCN
Structure:
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