Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50133231
Substrate
n/a
Meas. Tech.
ChEMBL_443936 (CHEMBL893102)
IC50
0.46±n/a nM
Citation
 Feng, Z; Mohapatra, S; Klimko, PG; Hellberg, MR; May, JA; Kelly, C; Williams, G; McLaughlin, MA; Sharif, NA Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity. Bioorg Med Chem Lett 17:2998-3002 (2007) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
  
Inhibitor
Name:
BDBM50133231
Synonyms:
(R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | (R)-2-(4-Iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | (R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine | CHEMBL134519
Type:
Small organic molecule
Emp. Form.:
C11H16INO2
Mol. Mass.:
321.1547
SMILES:
COc1cc(C[C@@H](C)N)c(OC)cc1I
Structure:
Search PDB for entries with ligand similarity: