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Target
Polyphenol oxidase 2
Ligand
BDBM50211055
Substrate
n/a
Meas. Tech.
ChEMBL_436307 (CHEMBL905708)
IC50
70±n/a nM
Citation
 Khatib, S; Nerya, O; Musa, R; Tamir, S; Peter, T; Vaya, J Enhanced substituted resorcinol hydrophobicity augments tyrosinase inhibition potency. J Med Chem 50:2676-81 (2007) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50211055
Synonyms:
3-(2,4-dihydroxyphenyl)-propionic acid isopropylester | CHEMBL228164
Type:
Small organic molecule
Emp. Form.:
C12H16O4
Mol. Mass.:
224.253
SMILES:
CC(C)OC(=O)CCc1ccc(O)cc1O
Structure:
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