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Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50213700
Substrate
n/a
Meas. Tech.
ChEMBL_438929 (CHEMBL889272)
EC50
4.3±n/a nM
Citation
 Zhang, R; Wang, A; DeAngelis, A; Pelton, P; Xu, J; Zhu, P; Zhou, L; Demarest, K; Murray, WV; Kuo, GH Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists. Bioorg Med Chem Lett 17:3855-9 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50213700
Synonyms:
2-(2-methyl-4-(2-propoxy-3-(4-(trifluoromethyl)phenoxy)propylthio)phenoxy)acetic acid | CHEMBL389769
Type:
Small organic molecule
Emp. Form.:
C22H25F3O5S
Mol. Mass.:
458.491
SMILES:
CCCOC(COc1ccc(cc1)C(F)(F)F)CSc1ccc(OCC(O)=O)c(C)c1 |w:4.4|
Structure:
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