Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM50214432
Substrate
n/a
Meas. Tech.
ChEMBL_439074 (CHEMBL889422)
IC50
113±n/a nM
Citation
 Kozikowski, AP; Chen, Y; Gaysin, A; Chen, B; D'Annibale, MA; Suto, CM; Langley, BC Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies. J Med Chem 50:3054-61 (2007) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50214432
Synonyms:
CHEMBL387924 | octanedioic acid hydroxyamide [4-(3-nitro-phenyl)thiazol-2-yl]amide
Type:
Small organic molecule
Emp. Form.:
C17H20N4O5S
Mol. Mass.:
392.429
SMILES:
ONC(=O)CCCCCCC(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: