Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50214705
Substrate
n/a
Meas. Tech.
ChEMBL_447604 (CHEMBL896618)
IC50
18.7±n/a nM
Citation
 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP. Bioorg Med Chem Lett 17:4173-7 (2007) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase
Type:
Enzyme
Mol. Mass.:
32035.18
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
289
Sequence:
MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
  
Inhibitor
Name:
BDBM50214705
Synonyms:
5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-difluoropentylphosphonate | 9-(5',5'-difluoro-5'-phosphonopentyl)guanine | 9-(5,5-DIFLUORO-5-PHOSPHONOPENTYL)GUANINE | CHEMBL236708 | [5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-1,1-difluoro-pentyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C10H14F2N5O4P
Mol. Mass.:
337.2198
SMILES:
Nc1nc2n(CCCCC(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: