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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50214871
Substrate
n/a
Meas. Tech.
ChEMBL_439337 (CHEMBL888453)
Ki
17±n/a nM
Citation
 Tang, G; Ding, K; Nikolovska-Coleska, Z; Yang, CY; Qiu, S; Shangary, S; Wang, R; Guo, J; Gao, W; Meagher, J; Stuckey, J; Krajewski, K; Jiang, S; Roller, PP; Wang, S Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins. J Med Chem 50:3163-6 (2007) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50214871
Synonyms:
1,4-bis(5,6,7-trihydroxy-8-isobutyl-2-methyl-4-oxo-4H-chromen-3-yl)benzene | CHEMBL226578
Type:
Small organic molecule
Emp. Form.:
C34H34O10
Mol. Mass.:
602.6278
SMILES:
CC(C)Cc1c(O)c(O)c(O)c2c1oc(C)c(-c1ccc(cc1)-c1c(C)oc3c(CC(C)C)c(O)c(O)c(O)c3c1=O)c2=O
Structure:
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