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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50216060
Substrate
n/a
Meas. Tech.
ChEMBL_439792 (CHEMBL888902)
Ki
22750±n/a nM
Citation
 Tu, Z; Xu, J; Jones, LA; Li, S; Dumstorff, C; Vangveravong, S; Chen, DL; Wheeler, KT; Welch, MJ; Mach, RH Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography. J Med Chem 50:3194-204 (2007) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50216060
Synonyms:
CHEMBL389261 | [N-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-2-(2-fluoro-ethoxy)-5-methyl-benzamide
Type:
Small organic molecule
Emp. Form.:
C23H29FN2O4
Mol. Mass.:
416.4858
SMILES:
COc1cc2CCN(CCNC(=O)c3cc(C)ccc3OCCF)Cc2cc1OC
Structure:
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