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Target
Thromboxane A2 receptor
Ligand
BDBM50218156
Substrate
n/a
Meas. Tech.
ChEMBL_444868 (CHEMBL894018)
IC50
871±n/a nM
Citation
 Hanson, J; Dogné, JM; Ghiotto, J; Moray, AL; Kinsella, BT; Pirotte, B Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as selective antagonists of the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor. J Med Chem 50:3928-36 (2007) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50218156
Synonyms:
CHEMBL244188 | N-n-pentyl-N'-[2-(4-chloroxyphenoxy)-5-nitrobenzenesulfonyl]urea
Type:
Small organic molecule
Emp. Form.:
C18H20ClN3O6S
Mol. Mass.:
441.886
SMILES:
CCCCCNC(=O)NS(=O)(=O)c1cc(ccc1Oc1ccc(Cl)cc1)[N+]([O-])=O
Structure:
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