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Target
Thrombopoietin receptor
Ligand
BDBM50219621
Substrate
n/a
Meas. Tech.
ChEMBL_457234 (CHEMBL941720)
EC50
27±n/a nM
Citation
 Reiter, LA; Subramanyam, C; Mangual, EJ; Jones, CS; Smeets, MI; Brissette, WH; McCurdy, SP; Lira, PD; Linde, RG; Li, Q; Zhang, F; Antipas, AS; Blumberg, LC; Doty, JL; Driscoll, JP; Munchhof, MJ; Ripp, SL; Shavnya, A; Shepard, RM; Sperger, D; Thomasco, LM; Trevena, KA; Wolf-Gouveia, LA; Zhang, L Pyrimidine benzamide-based thrombopoietin receptor agonists. Bioorg Med Chem Lett 17:5447-54 (2007) [PubMed]  Article 
Target
Name:
Thrombopoietin receptor
Synonyms:
C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
71243.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_535587
Residue:
635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
  
Inhibitor
Name:
BDBM50219621
Synonyms:
4-(pyrimidin-4-ylamino)-N-(7-trifluoromethyl-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-benzamide | CHEMBL245795
Type:
Small organic molecule
Emp. Form.:
C23H16F3N5O2S
Mol. Mass.:
483.466
SMILES:
FC(F)(F)c1cccc2-c3nc(NC(=O)c4ccc(Nc5ccncn5)cc4)sc3CCOc12
Structure:
Search PDB for entries with ligand similarity: