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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50223277
Substrate
n/a
Meas. Tech.
ChEMBL_458156 (CHEMBL924413)
Ki
47±n/a nM
Citation
 Tasler, S; Kraus, J; Wuzik, A; Müller, O; Aschenbrenner, A; Cubero, E; Pascual, R; Quintana-Ruiz, JR; Dordal, A; Mercè, R; Codony, X Discovery of 5-HT6 receptor ligands based on virtual HTS. Bioorg Med Chem Lett 17:6224-9 (2007) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50223277
Synonyms:
2-(benzylamino)-4-(4-methylpiperazin-1-yl)benzonitrile | CHEMBL250401
Type:
Small organic molecule
Emp. Form.:
C19H22N4
Mol. Mass.:
306.4048
SMILES:
CN1CCN(CC1)c1ccc(C#N)c(NCc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: