Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50224807
Substrate
n/a
Meas. Tech.
ChEMBL_459690 (CHEMBL942822)
IC50
>500000±n/a nM
Citation
Baumann, HI; Keller, S; Wolter, FE; Nicholson, GJ; Jung, G; Süssmuth, RD; Jüttner, F Planktocyclin, a cyclooctapeptide protease inhibitor produced by the freshwater cyanobacterium Planktothrix rubescens. J Nat Prod 70:1611-5 (2007) [PubMed] Article
More Info.:
Target
Name:
Cathepsin B
Synonyms:
BCSB | CATB_BOVIN | CTSB | Cathepsin B precursor | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
36657.87
Organism:
Bos taurus (bovine)
Description:
Bovine spleen CB was purchased from Sigma Co. (USA).
Residue:
335
Sequence:
MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY
Inhibitor
Name:
BDBM50224807
Synonyms:
CHEMBL400366 | cyclo(Pro-Gly-Leu-Val-Met-Phe-Gly-Val)
Type:
Small organic molecule
Emp. Form.:
C39H60N8O8S
Mol. Mass.:
801.007
SMILES:
CSCC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC1=O)C(C)C)C(C)C