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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50225997
Substrate
n/a
Meas. Tech.
ChEMBL_451825 (CHEMBL902037)
IC50
340.4±n/a nM
Citation
 Marma, MS; Xia, Z; Stewart, C; Coxon, F; Dunford, JE; Baron, R; Kashemirov, BA; Ebetino, FH; Triffitt, JT; Russell, RG; McKenna, CE Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. J Med Chem 50:5967-75 (2007) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Homo sapiens (Human)
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
  
Inhibitor
Name:
BDBM50225997
Synonyms:
1-bromo-2-(3-pyridinyl)-ethylidene-1,1-bisphosphonic acid | CHEMBL394759
Type:
Small organic molecule
Emp. Form.:
C7H10BrNO6P2
Mol. Mass.:
346.009
SMILES:
OP(O)(=O)C(Br)(Cc1cccnc1)P(O)(O)=O
Structure:
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