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Target
Histamine H1 receptor
Ligand
BDBM50226008
Substrate
n/a
Meas. Tech.
ChEMBL_458732 (CHEMBL943016)
Ki
>2000±n/a nM
Citation
 Blagg, J; Allerton, CM; Batchelor, DV; Baxter, AD; Burring, DJ; Carr, CL; Cook, AS; Nichols, CL; Phipps, J; Sanderson, VG; Verrier, H; Wong, S Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route. Bioorg Med Chem Lett 17:6691-6 (2007) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50226008
Synonyms:
(R)-3-(4-propylmorpholin-2-yl)phenol | CHEMBL250403
Type:
Small organic molecule
Emp. Form.:
C13H19NO2
Mol. Mass.:
221.2955
SMILES:
CCCN1CCO[C@@H](C1)c1cccc(O)c1
Structure:
Search PDB for entries with ligand similarity: