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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50229214
Substrate
n/a
Meas. Tech.
ChEMBL_461774 (CHEMBL927780)
EC50
>25000±n/a nM
Citation
 Faucher, N; Martres, P; Laroze, A; Pineau, O; Potvain, F; Grillot, D Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. Bioorg Med Chem Lett 18:710-5 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
Nr1c1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA_MOUSE | Peroxisome Proliferator-Activated Receptor alpha | Ppar | Ppara
Type:
PROTEIN
Mol. Mass.:
52343.28
Organism:
Mus musculus
Description:
ChEMBL_572395
Residue:
468
Sequence:
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50229214
Synonyms:
2-(4-{[(4'-cyano-biphenyl-4-carbonyl)-amino]-methyl}-phenoxy)-2-methyl-propionic acid | CHEMBL401560
Type:
Small organic molecule
Emp. Form.:
C25H22N2O4
Mol. Mass.:
414.4532
SMILES:
CC(C)(Oc1ccc(CNC(=O)c2ccc(cc2)-c2ccc(cc2)C#N)cc1)C(O)=O
Structure:
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