Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50229226
Substrate
n/a
Meas. Tech.
ChEMBL_461774 (CHEMBL927780)
EC50
700±n/a nM
Citation
 Faucher, N; Martres, P; Laroze, A; Pineau, O; Potvain, F; Grillot, D Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. Bioorg Med Chem Lett 18:710-5 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
Nr1c1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA_MOUSE | Peroxisome Proliferator-Activated Receptor alpha | Ppar | Ppara
Type:
PROTEIN
Mol. Mass.:
52343.28
Organism:
Mus musculus
Description:
ChEMBL_572395
Residue:
468
Sequence:
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50229226
Synonyms:
CHEMBL401562 | N-(4-(trifluoromethylsulfonamido)benzyl)-4-(5-(methoxymethyl)-1,2,4-oxadiazol-3-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C19H17F3N4O5S
Mol. Mass.:
470.422
SMILES:
COCc1nc(no1)-c1ccc(cc1)C(=O)NCc1ccc(NS(=O)(=O)C(F)(F)F)cc1
Structure:
Search PDB for entries with ligand similarity: