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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50229215
Substrate
n/a
Meas. Tech.
ChEMBL_461774 (CHEMBL927780)
EC50
>10000±n/a nM
Citation
 Faucher, N; Martres, P; Laroze, A; Pineau, O; Potvain, F; Grillot, D Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. Bioorg Med Chem Lett 18:710-5 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
Nr1c1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA_MOUSE | Peroxisome Proliferator-Activated Receptor alpha | Ppar | Ppara
Type:
PROTEIN
Mol. Mass.:
52343.28
Organism:
Mus musculus
Description:
ChEMBL_572395
Residue:
468
Sequence:
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50229215
Synonyms:
CHEMBL254540 | N-(4-((2H-tetrazol-5-yl)methoxy)benzyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamide
Type:
Small organic molecule
Emp. Form.:
C21H17F3N6O2S
Mol. Mass.:
474.459
SMILES:
Cc1nc(sc1C(=O)NCc1ccc(OCc2nnn[nH]2)cc1)-c1ccc(cc1)C(F)(F)F
Structure:
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