Reaction Details Report a problem with these data
Target
Macrophage infectivity potentiator
Ligand
BDBM50659607
Substrate
n/a
Meas. Tech.
ChEMBL_2627791
Ki
1000±n/a nM
Citation
 Pérez Carrillo, VH; Whittaker, JJ; Wiedemann, C; Harder, JM; Lohr, T; Jamithireddy, AK; Dajka, M; Goretzki, B; Joseph, B; Guskov, A; Harmer, NJ; Holzgrabe, U; Hellmich, UA Structure and Dynamics of Macrophage Infectivity Potentiator Proteins from Pathogenic Bacteria and Protozoans Bound to Fluorinated Pipecolic Acid Inhibitors. J Med Chem 68:5926-5941[PubMed] 
Target
Name:
Macrophage infectivity potentiator
Synonyms:
5.2.1.8 | Macrophage infectivity potentiator | MIP | Peptidyl-prolyl cis-trans isomerase | PPIase | Rotamase
Type:
PROTEIN
Mol. Mass.:
22137.45
Organism:
Trypanosoma cruzi
Description:
ChEMBL_124041
Residue:
196
Sequence:
MHRENYFSKIAFCLLGVLFLSCITSVQTVSGDAASHEERMNNYRKRVGRLFMEQKAAQPDAVKLPSGLVFQRIARGSGKRAPAIDDKCEVHYTGRLRDGTVFDSSRERGKPTTFRPNEVIKGWTEALQLMREGDRWRLFIPYDLAYGVTGGGGMIPPYSPLEFDVELISIKDGGKGRTAEEVDEILRKAEEDREDM
  
Inhibitor
Name:
BDBM50659607
Synonyms:
CHEMBL5395490
Type:
Small organic molecule
Emp. Form.:
C28H30F2N4O4S
Mol. Mass.:
556.64
SMILES:
c1cc(cnc1)CNC(=O)[C@H](Cc2ccc(cc2)F)NC(=O)[C@@H]3CCCCN3S(=O)(=O)Cc4ccc(cc4)F
Structure:
Search PDB for entries with ligand similarity: