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Target
DNA polymerase beta
Ligand
BDBM50250305
Substrate
n/a
Meas. Tech.
ChEMBL_528612 (CHEMBL973957)
IC50
4700±n/a nM
Citation
 Deng, JZ; Starck, SR; Hecht, SM; Ijames, CF; Hemling, ME Harbinatic acid, a novel and potent DNA polymerase beta inhibitor from Hardwickia binata. J Nat Prod 62:1000-2 (1999) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA Polymerase beta | DPOLB_RAT | Polb
Type:
PROTEIN
Mol. Mass.:
38334.34
Organism:
Rattus norvegicus
Description:
ChEMBL_1361926
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
  
Inhibitor
Name:
BDBM50250305
Synonyms:
3alpha-O-trans-p-coumaroyl-7-labden-15-oic acid | CHEMBL494656
Type:
Small organic molecule
Emp. Form.:
C28H38O5
Mol. Mass.:
454.5983
SMILES:
C[C@@H](CC[C@@H]1[C@H]2CC[C@H](OC(=O)\C=C\c3ccc(O)cc3)C(C)(C)[C@@H]2CC=C1C)CC(O)=O |r,c:28|
Structure:
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