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Target
DNA polymerase beta
Ligand
BDBM50250361
Substrate
n/a
Meas. Tech.
ChEMBL_528872 (CHEMBL978545)
IC50
36000±n/a nM
Citation
 Sun, DA; Starck, SR; Locke, EP; Hecht, SM DNA polymerase beta inhibitors from Sandoricum koetjape. J Nat Prod 62:1110-3 (1999) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA Polymerase beta | DPOLB_RAT | Polb
Type:
PROTEIN
Mol. Mass.:
38334.34
Organism:
Rattus norvegicus
Description:
ChEMBL_1361926
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
  
Inhibitor
Name:
BDBM50250361
Synonyms:
3-methyloximo-olean-12-en-29-oic acid | CHEMBL524160
Type:
Small organic molecule
Emp. Form.:
C31H49NO3
Mol. Mass.:
483.7257
SMILES:
CO\N=C1\CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC=C2[C@@H]4C[C@@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C |r,t:16|
Structure:
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