Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 5
Ligand
BDBM50242056
Substrate
n/a
Meas. Tech.
ChEMBL_550952 (CHEMBL1000792)
IC50
20000±n/a nM
Citation
 Jayasuriya, H; Herath, KB; Ondeyka, JG; Polishook, JD; Bills, GF; Dombrowski, AW; Springer, MS; Siciliano, S; Malkowitz, L; Sanchez, M; Guan, Z; Tiwari, S; Stevenson, DW; Borris, RP; Singh, SB Isolation and structure of antagonists of chemokine receptor (CCR5). J Nat Prod 67:1036-8 (2004) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50242056
Synonyms:
CHEMBL469856 | fuscinarin
Type:
Small organic molecule
Emp. Form.:
C14H16O5
Mol. Mass.:
264.2738
SMILES:
CC1OC(=O)c2c1c(O)c(O)c1OC(C)(C)CCc21
Structure:
Search PDB for entries with ligand similarity: