Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM50241877
Substrate
n/a
Meas. Tech.
ChEMBL_551129 (CHEMBL1007710)
EC50
>50000±n/a nM
Citation
Jayasuriya, H; Herath, KB; Ondeyka, JG; Guan, Z; Borris, RP; Tiwari, S; de Jong, W; Chavez, F; Moss, J; Stevenson, DW; Beck, HT; Slattery, M; Zamora, N; Schulman, M; Ali, A; Sharma, N; MacNaul, K; Hayes, N; Menke, JG; Singh, SB Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. J Nat Prod 68:1247-52 (2005) [PubMed] Article
More Info.:
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Inhibitor
Name:
BDBM50241877
Synonyms:
((1R,4aR,7S,8aS,10aS)-1,4a,7-trimethyl-7-vinyl-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydrophenanthren-1-yl)methanol | CHEMBL470040
Type:
Small organic molecule
Emp. Form.:
C20H32O
Mol. Mass.:
288.4675
SMILES:
C[C@@]1(CC=C2[C@@H](CC[C@@H]3[C@](C)(CO)CCC[C@@]23C)C1)C=C |r,c:3|