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Target
Glycine receptor subunit alpha-2
Ligand
BDBM50269961
Substrate
n/a
Meas. Tech.
ChEMBL_505470 (CHEMBL944605)
IC50
117300±n/a nM
Citation
 Wang, DS; Buckinx, R; Lecorronc, H; Mangin, JM; Rigo, JM; Legendre, P Mechanisms for picrotoxinin and picrotin blocks of alpha2 homomeric glycine receptors. J Biol Chem 282:16016-35 (2007) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-2
Synonyms:
GLRA2_RAT | Glra2 | Glycine receptor alpha-2 chain
Type:
PROTEIN
Mol. Mass.:
52066.64
Organism:
Rattus norvegicus
Description:
ChEMBL_505470
Residue:
452
Sequence:
MNRQLVNILTALFAFFLGTNHFREAFCKDHDSRSGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFEYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
  
Inhibitor
Name:
BDBM50269961
Synonyms:
CHEMBL478523 | picrotin
Type:
Small organic molecule
Emp. Form.:
C15H18O7
Mol. Mass.:
310.2992
SMILES:
CC(C)(O)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]1(O)C[C@H]3O[C@]33C(=O)O[C@H]2[C@]13C |r,TLB:8:7:4:10.19.20|
Structure:
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