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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50266501
Substrate
n/a
Meas. Tech.
ChEMBL_544083 (CHEMBL1019543)
EC50
1120±n/a nM
Citation
 Yu, J; Tang, L; Yang, Y; Ji, R Synthesis and evaluation of a series of benzopyran derivatives as PPAR alpha/gamma agonists. Eur J Med Chem 43:2428-35 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50266501
Synonyms:
CHEMBL455853 | Methyl 7-(2-(2-(biphenyl-4-yl)-5-methyloxazol-4-yl)ethoxy)-2-oxochroman-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C29H25NO6
Mol. Mass.:
483.5119
SMILES:
COC(=O)C1Cc2ccc(OCCc3nc(oc3C)-c3ccc(cc3)-c3ccccc3)cc2OC1=O
Structure:
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