Reaction Details Report a problem with these data
Target
Bcl2-associated agonist of cell death
Ligand
BDBM50270876
Substrate
n/a
Meas. Tech.
ChEMBL_553538 (CHEMBL958721)
IC50
6900±n/a nM
Citation
 Congreve, M; Chessari, G; Tisi, D; Woodhead, AJ Recent developments in fragment-based drug discovery. J Med Chem 51:3661-80 (2008) [PubMed]  Article 
Target
Name:
Bcl2-associated agonist of cell death
Synonyms:
BAD | BAD_HUMAN | BBC6 | BCL2L8 | Bcl-2-binding component 6 | Bcl-2-like protein 8 | Bcl-XL/Bcl-2-associated death promoter | Bcl2 antagonist of cell death | Bcl2-L-8 | Bcl2-antagonist of cell death (BAD)
Type:
PROTEIN
Mol. Mass.:
18393.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_478760
Residue:
168
Sequence:
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
  
Inhibitor
Name:
BDBM50270876
Synonyms:
3-((E)-2-Biphenyl-3-yl-vinyl)-4'-fluoro-biphenyl-4-carboxylic acid | CHEMBL485891
Type:
Small organic molecule
Emp. Form.:
C27H19FO2
Mol. Mass.:
394.437
SMILES:
OC(=O)c1ccc(cc1\C=C\c1cccc(c1)-c1ccccc1)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: