Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50248785
Substrate
n/a
Meas. Tech.
ChEMBL_542152 (CHEMBL1009862)
Ki
26±n/a nM
Citation
 Bojarski, AJ; Kuran, B; Kossakowski, J; Koziol, A; Jagiello-Wójtowicz, E; Chodkowska, A Synthesis and serotonin receptor activity of the arylpiperazine alkyl/propoxy derivatives of new azatricycloundecanes. Eur J Med Chem 44:152-64 (2008) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50248785
Synonyms:
1-Ethoxy-4-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-4-aza-tricyclo[5.2.2.0*2,6*]undecane-3,5,8-trione | CHEMBL473996
Type:
Small organic molecule
Emp. Form.:
C27H37N3O5
Mol. Mass.:
483.5998
SMILES:
CCOC12CCC(C3C1C(=O)N(CCCCN1CCN(CC1)c1ccccc1OC)C3=O)C(=O)C2 |THB:33:32:8.7:5.4|
Structure:
Search PDB for entries with ligand similarity: