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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50292598
Substrate
n/a
Meas. Tech.
ChEMBL_492080 (CHEMBL946246)
IC50
432±n/a nM
Citation
 Bozdağ-Dündar, O; Verspohl, EJ; Das-Evcimen, N; Kaup, RM; Bauer, K; Sarikaya, M; Evranos, B; Ertan, R Synthesis and biological activity of some new flavonyl-2,4-thiazolidinediones. Bioorg Med Chem 16:6747-51 (2008) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50292598
Synonyms:
5-((4-(4-oxo-4H-chromen-2-yl)phenyl)methylene)thiazolidine-2,4-dione | CHEMBL494695
Type:
Small organic molecule
Emp. Form.:
C19H11NO4S
Mol. Mass.:
349.36
SMILES:
O=C1NC(=O)\C(S1)=C\c1ccc(cc1)-c1cc(=O)c2ccccc2o1
Structure:
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