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Target
Procathepsin L
Ligand
BDBM50252524
Substrate
n/a
Meas. Tech.
ChEMBL_487507 (CHEMBL1012296)
IC50
130±n/a nM
Citation
 Kim, SH; Jhon, DJ; Song, JH; No, JS; Kang, NS Effect of novel N-cyano-tetrahydro-pyridazine compounds, a class of cathepsin K inhibitors, on the bone resorptive activity of mature osteoclasts. Bioorg Med Chem Lett 18:3988-91 (2008) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50252524
Synonyms:
CHEMBL493018 | tert-butyl 1-(2-cyanopiperazin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate
Type:
Small organic molecule
Emp. Form.:
C15H26N4O3
Mol. Mass.:
310.3919
SMILES:
CC(C)C(NC(=O)OC(C)(C)C)C(=O)N1CCCCN1C#N
Structure:
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