Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50252128
Substrate
n/a
Meas. Tech.
ChEMBL_487560 (CHEMBL1013154)
Ki
10.7±n/a nM
Citation
 Zhou, D; Zhou, P; Evrard, DA; Meagher, K; Webb, M; Harrison, BL; Huryn, DM; Golembieski, J; Hornby, GA; Schechter, LE; Smith, DL; Andree, TH; Mewshaw, RE Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives. Bioorg Med Chem 16:6707-23 (2008) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50252128
Synonyms:
4-{cis-4-[4-(1H-Indol-3-yl)cyclohexyl]-piperazin-1-yl}-2-methyl-1H-benzimidazole | CHEMBL481523
Type:
Small organic molecule
Emp. Form.:
C26H31N5
Mol. Mass.:
413.5578
SMILES:
Cc1nc2c(cccc2[nH]1)N1CCN(CC1)[C@H]1CC[C@H](CC1)c1c[nH]c2ccccc12 |r,wU:16.18,19.25,(-18.8,-3.58,;-18.81,-5.12,;-17.56,-6.03,;-18.04,-7.5,;-17.29,-8.84,;-18.06,-10.17,;-19.61,-10.17,;-20.38,-8.82,;-19.58,-7.49,;-20.06,-6.02,;-15.74,-8.85,;-14.99,-10.18,;-13.44,-10.19,;-12.66,-8.86,;-13.43,-7.52,;-14.96,-7.51,;-11.12,-8.87,;-10.34,-7.54,;-8.79,-7.56,;-8.03,-8.9,;-8.82,-10.23,;-10.36,-10.22,;-6.5,-8.92,;-5.61,-10.16,;-4.14,-9.7,;-4.13,-8.17,;-2.99,-7.17,;-3.29,-5.66,;-4.74,-5.18,;-5.89,-6.19,;-5.59,-7.68,)|
Structure:
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