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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50252537
Substrate
n/a
Meas. Tech.
ChEMBL_487560 (CHEMBL1013154)
Ki
33.5±n/a nM
Citation
 Zhou, D; Zhou, P; Evrard, DA; Meagher, K; Webb, M; Harrison, BL; Huryn, DM; Golembieski, J; Hornby, GA; Schechter, LE; Smith, DL; Andree, TH; Mewshaw, RE Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives. Bioorg Med Chem 16:6707-23 (2008) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50252537
Synonyms:
6-Fluoro-3-[cis-4-[4-(1H-indol-4-yl)-1-piperazinyl]cyclohexyl]-1H-indole | CHEMBL522671
Type:
Small organic molecule
Emp. Form.:
C26H29FN4
Mol. Mass.:
416.5337
SMILES:
Fc1ccc2c(c[nH]c2c1)[C@@H]1CC[C@@H](CC1)N1CCN(CC1)c1cccc2[nH]ccc12 |r,wU:13.18,10.11,(20.51,-14.6,;19.37,-13.55,;17.91,-14.01,;16.78,-12.97,;17.12,-11.48,;16.22,-10.23,;17.14,-9,;18.6,-9.49,;18.58,-11.03,;19.71,-12.06,;14.69,-10.22,;13.93,-8.88,;12.38,-8.86,;11.61,-10.19,;12.37,-11.53,;13.9,-11.54,;10.07,-10.18,;9.29,-11.51,;7.75,-11.49,;7,-10.16,;7.77,-8.83,;9.31,-8.83,;5.46,-10.16,;4.7,-8.82,;3.16,-8.81,;2.38,-10.14,;3.14,-11.49,;2.67,-12.96,;3.92,-13.86,;5.17,-12.95,;4.69,-11.48,)|
Structure:
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