Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50263003
Substrate
n/a
Meas. Tech.
ChEMBL_489270 (CHEMBL990826)
IC50
14±n/a nM
Citation
 Oslund, RC; Cermak, N; Gelb, MH Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J Med Chem 51:4708-14 (2008) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50263003
Synonyms:
2-(2-ethyl-3-(o-phenylbenzyl)-8-(2-oxopropoxy)indolizin-1-yl)-2-oxoacetamide | CHEMBL514841
Type:
Small organic molecule
Emp. Form.:
C24H22N2O3
Mol. Mass.:
386.4431
SMILES:
CCc1c(C(=O)C(N)=O)c2c(OC)cc3ccccc3c2n1Cc1ccccc1
Structure:
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