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Target
Bone morphogenetic protein 4
Ligand
BDBM5416
Substrate
n/a
Meas. Tech.
ChEMBL_490878 (CHEMBL989154)
IC50
2000±n/a nM
Citation
 Cuny, GD; Yu, PB; Laha, JK; Xing, X; Liu, JF; Lai, CS; Deng, DY; Sachidanandan, C; Bloch, KD; Peterson, RT Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett 18:4388-92 (2008) [PubMed]  Article 
Target
Name:
Bone morphogenetic protein 4
Synonyms:
BMP2B | BMP4 | BMP4_HUMAN | DVR4
Type:
PROTEIN
Mol. Mass.:
46572.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1363193
Residue:
408
Sequence:
MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
  
Inhibitor
Name:
BDBM5416
Synonyms:
4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl]phenoxy}ethyl)morpholine | CHEMBL324153 | dorsomorphin (6K1) | pyrazolo[1,5-a]pyrimidine 4h
Type:
Small organic molecule
Emp. Form.:
C23H23N5O2
Mol. Mass.:
401.461
SMILES:
C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: