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Target
Kappa-type opioid receptor
Ligand
BDBM50272412
Substrate
n/a
Meas. Tech.
ChEMBL_510208 (CHEMBL1004824)
EC50
1000±n/a nM
Citation
 Hilfiker, MA; Zhang, D; Dowdell, SE; Goodman, KB; McAtee, JJ; Dodson, JW; Viet, AQ; Wang, GZ; Sehon, CA; Behm, DJ; Wu, Z; Carballo, LH; Douglas, SA; Neeb, MJ Aminomethylpiperazines as selective urotensin antagonists. Bioorg Med Chem Lett 18:4470-3 (2008) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50272412
Synonyms:
3-(2-oxo-2-(4-(phenylsulfonyl)-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl)ethyl)benzo[d]oxazol-2(3H)-one | CHEMBL524288
Type:
Small organic molecule
Emp. Form.:
C24H28N4O5S
Mol. Mass.:
484.568
SMILES:
O=C(Cn1c2ccccc2oc1=O)N1CCN(CC1CN1CCCC1)S(=O)(=O)c1ccccc1
Structure:
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