Target
Protein kinase C alpha type
Ligand
BDBM50244971
Substrate
n/a
Meas. Tech.
ChEMBL_512395 (CHEMBL979906)
Ki
134±n/a nM
Citation
 Duan, DSigano, DMKelley, JALai, CCLewin, NEKedei, NPeach, MLLee, JAbeyweera, TPRotenberg, SAKim, HKim, YHEl Kazzouli, SChung, JUYoung, HAYoung, MRBaker, AColburn, NHHaimovitz-Friedman, ATruman, JPParrish, DADeschamps, JRPerry, NASurawski, RJBlumberg, PMMarquez, VE Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. J Med Chem 51:5198-220 (2008) [PubMed]  Article 
Target
Name:
Protein kinase C alpha type
Synonyms:
KPCA_MOUSE | Pkca | Prkca | Protein kinase C | Protein kinase C alpha | Protein kinase C alpha type
Type:
Enzyme Catalytic Domain
Mol. Mass.:
76858.67
Organism:
MOUSE
Description:
Protein kinase C 0 MOUSE::P20444
Residue:
672
Sequence:
MADVYPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINDPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSNLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKAHNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPVGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLNNVMLNSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKQPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
  
Inhibitor
Name:
BDBM50244971
Synonyms:
CHEMBL471317 | rac-(E)-{2-(Hydroxymethyl)-4-[(2-nitrophenyl)methylene]-5-oxo-2-2,3-dihydrofuryl}methyl 2-(Dimethylamino)benzoate
Type:
Small organic molecule
Emp. Form.:
C22H22N2O7
Mol. Mass.:
426.4193
SMILES:
CN(C)c1ccccc1C(=O)OCC1(CO)C\C(=C/c2ccccc2[N+]([O-])=O)C(=O)O1
Structure:
Search PDB for entries with ligand similarity: