Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50265122
Substrate
n/a
Meas. Tech.
ChEMBL_492630 (CHEMBL953059)
IC50
8.7±n/a nM
Citation
 Cherney, RJ; Nelson, DJ; Lo, YC; Yang, G; Scherle, PA; Jezak, H; Solomon, KA; Carter, PH; Decicco, CP Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists. Bioorg Med Chem Lett 18:5063-5 (2008) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50265122
Synonyms:
(+/-)-N-(2-(2-(4-(4-(methylthio)benzylamino)-1-propylpiperidin-3-ylamino)-2-oxoethylcarbamoyl)-4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide | CHEMBL449672
Type:
Small organic molecule
Emp. Form.:
C31H41F3N6O3S
Mol. Mass.:
634.756
SMILES:
CCCN1CCC(NCc2ccc(SC)cc2)C(C1)NC(=O)CNC(=O)c1cc(ccc1NC(=O)N1CCCC1)C(F)(F)F
Structure:
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