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Target
Squalene synthase
Ligand
BDBM50253937
Substrate
n/a
Meas. Tech.
ChEMBL_512553 (CHEMBL967864)
IC50
1000±n/a nM
Citation
 Kourounakis, AP; Charitos, C; Rekka, EA; Kourounakis, PN Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. J Med Chem 51:5861-5 (2008) [PubMed]  Article 
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
  
Inhibitor
Name:
BDBM50253937
Synonyms:
2-[4-(2-Bromo-5-thienyl)phenyl]-4-methyl-octahydro-1,4-benzoxazin-2-ol | CHEMBL516943
Type:
Small organic molecule
Emp. Form.:
C19H22BrNO2S
Mol. Mass.:
408.352
SMILES:
CN1CC(O)(OC2CCCCC12)c1ccc(cc1)-c1ccc(Br)s1
Structure:
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