Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM23517
Substrate
n/a
Meas. Tech.
ChEMBL_535373 (CHEMBL983499)
EC50
12500±n/a nM
Citation
 Deng, Q; Frie, JL; Marley, DM; Beresis, RT; Ren, N; Cai, TQ; Taggart, AK; Cheng, K; Carballo-Jane, E; Wang, J; Tong, X; Waters, MG; Tata, JR; Colletti, SL Molecular modeling aided design of nicotinic acid receptor GPR109A agonists. Bioorg Med Chem Lett 18:4963-7 (2008) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM23517
Synonyms:
2-[2-(4-methoxyphenoxy)acetamido]benzoic acid | Biaryl Anthranilide Analogue, 1a | CHEMBL228244
Type:
Small organic molecule
Emp. Form.:
C16H15NO5
Mol. Mass.:
301.294
SMILES:
COc1ccc(OCC(=O)Nc2ccccc2C(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: