Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50263902
Substrate
n/a
Meas. Tech.
ChEMBL_535520 (CHEMBL986146)
EC50
8580±n/a nM
Citation
 Kim, EPark, CSHan, TBae, MHChong, WLee, CHShin, YAAhn, BNKim, MKShin, CYSon, MHKim, JKMoon, HSShim, HJKim, EJKim, SHLim, JILee, CH Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARalpha/gamma dual agonists. Bioorg Med Chem Lett 18:4993-6 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50263902
Synonyms:
2-ethoxy-3-(4-(2-(4-(thiophen-2-yl)-5,6-dihydropyridin-1(2H)-yl)ethoxy)phenyl)propanoic acid | CHEMBL491423
Type:
Small organic molecule
Emp. Form.:
C22H27NO4S
Mol. Mass.:
401.519
SMILES:
CCOC(Cc1ccc(OCCN2CCC(=CC2)c2cccs2)cc1)C(O)=O |c:15|
Structure:
Search PDB for entries with ligand similarity: