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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50110788
Substrate
n/a
Meas. Tech.
ChEMBL_492712 (CHEMBL938512)
Ki
325±n/a nM
Citation
 Mavel, S; Vercouillie, J; Garreau, L; Raguza, T; Ravna, AW; Chalon, S; Guilloteau, D; Emond, P Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging. Bioorg Med Chem 16:9050-5 (2008) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50110788
Synonyms:
2-(2-((dimethylamino)methyl)phenylthio)-5-methylaniline | 2-(2-((dimethylamino)methyl)phenylthio)-5-methylbenzenamine | 2-(2-Dimethylaminomethyl-phenylsulfanyl)-5-methyl-phenylamine | CHEMBL22183 | MADAM | N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine
Type:
Small organic molecule
Emp. Form.:
C16H20N2S
Mol. Mass.:
272.408
SMILES:
CN(C)Cc1ccccc1Sc1ccc(C)cc1N
Structure:
Search PDB for entries with ligand similarity: