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Target
Kappa-type opioid receptor
Ligand
BDBM50252856
Substrate
n/a
Meas. Tech.
ChEMBL_534709 (CHEMBL982798)
Ki
92.8±n/a nM
Citation
 Ghosh, A; Luo, J; Liu, C; Weltrowska, G; Lemieux, C; Chung, NN; Lu, Y; Schiller, PW Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp]. J Med Chem 51:5866-70 (2008) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50252856
Synonyms:
(4S,7S,13S)-13-[(S)-3-(4-Hydroxy-2,6-dimethyl-phenyl)-2-methyl-propionylamino]-7-(4-nitro-benzyl)-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradecane-4-carboxylic acid amide | CHEMBL503771
Type:
Small organic molecule
Emp. Form.:
C29H36N6O8S2
Mol. Mass.:
660.762
SMILES:
C[C@@H](Cc1c(C)cc(O)cc1C)C(=O)N[C@@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc(cc2)[N+]([O-])=O)NC(=O)CNC1=O)C(N)=O |r|
Structure:
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