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Target
Cytochrome P450 2D6
Ligand
BDBM50263397
Substrate
n/a
Meas. Tech.
ChEMBL_536100 (CHEMBL995046)
IC50
>50000±n/a nM
Citation
 Jolidon, S; Alberati, D; Dowle, A; Fischer, H; Hainzl, D; Narquizian, R; Norcross, R; Pinard, E Design, synthesis and structure-activity relationship of simple bis-amides as potent inhibitors of GlyT1. Bioorg Med Chem Lett 18:5533-6 (2008) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50263397
Synonyms:
(+)-4-chloro-N-(2-((4-chlorophenyl)(phenyl)methylamino)-2-oxoethyl)benzamide | (-)-4-chloro-N-(2-((4-chlorophenyl)(phenyl)methylamino)-2-oxoethyl)benzamide | 4-chloro-N-(2-((4-chlorophenyl)(phenyl)methylamino)-2-oxoethyl)benzamide | CHEMBL475928
Type:
Small organic molecule
Emp. Form.:
C22H18Cl2N2O2
Mol. Mass.:
413.297
SMILES:
Clc1ccc(cc1)C(NC(=O)CNC(=O)c1ccc(Cl)cc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: