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Target
Cyclin-dependent kinase 2
Ligand
BDBM5929
Substrate
n/a
Meas. Tech.
ChEMBL_557990 (CHEMBL965585)
IC50
20±n/a nM
Citation
 Fan, J; Fahr, B; Stockett, D; Chan, E; Cheeti, S; Serafimova, I; Lu, Y; Pham, P; Walker, DH; Hoch, U; Choong, IC Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio. Bioorg Med Chem Lett 18:6236-9 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM5929
Synonyms:
(+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-3-piperidinecarboxamide | BMS-387032 analog 19 | CHEMBL297570 | N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C17H24N4O2S2
Mol. Mass.:
380.528
SMILES:
CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCCNC3)s2)o1
Structure:
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