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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50245945
Substrate
n/a
Meas. Tech.
ChEMBL_558110 (CHEMBL959039)
EC50
32±n/a nM
Citation
 Martres, P; Faucher, N; Laroze, A; Pineau, O; Fouchet, MH; Potvain, F; Grillot, D; Beneton, V The discovery of equipotent PPARalpha/gamma dual activators. Bioorg Med Chem Lett 18:6251-4 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50245945
Synonyms:
2-(4-((1-allyl-5-(4-tert-butylphenyl)-1H-pyrazole-3-carboxamido)methyl)-2-methylphenoxy)-2-methylpropanoic acid | CHEMBL516964
Type:
Small organic molecule
Emp. Form.:
C29H35N3O4
Mol. Mass.:
489.6059
SMILES:
Cc1cc(CNC(=O)c2cc(-c3ccc(cc3)C(C)(C)C)n(CC=C)n2)ccc1OC(C)(C)C(O)=O
Structure:
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